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myc genes การใช้

ประโยคมือถือ
  • Myc gene was first discovered in Burkitt lymphoma patients.
  • Amplification of the MYC gene was found in a significant number of epithelial ovarian cancer cases.
  • Myc protein belongs to Myc family of transcription factors, which also includes N-Myc and L-Myc genes.
  • In the experimental transformation process of normal cells into cancer cells, the MYC gene can cooperate with the RAS gene.
  • This viral gene insertion is also known as a promoter insertion as it drives the expression of the c-myc gene.
  • Researchers said the finding may help develop drugs that will block the signal that causes the c-MYC gene to turn on.
  • Female adipose cells, lung fibroblasts, and foreskin fibroblasts were reprogrammed into induced pluripotent state with the OCT4, SOX2, KLF4, and MYC genes.
  • Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers.
  • Through chromatin immunoprecipitation assays, it was shown that HDAC7 directly binds with the c-Myc gene and therefore HDAC7 silencing decreased c-Myc mRNA levels.
  • In leukemia cell lines, CAPP is actively brought into cells for downstream regulation of the c-myc gene through ceramide-induced control ( Wolff et al, 1994 ).
  • The generation of ceramide can cause down-regulation of the c-myc gene, which can trigger a cellular cascade resulting in cell death through apoptotic mechanisms ( Wolff et al, 1994 ).
  • When the gene is mutated, either through heredity or as the result of exposure to certain chemicals, it then sends a signal to the c-MYC gene that causes cells to multiply out of control, the study found.
  • The c-myc gene is normally turned off in the cell; however when it is turned on it is able to push the cell into the G1 phase of the cell cycle and cause the cell to begin replication, causing unchecked cell proliferation while allowing the viral gene to be replicated.
  • The mammalian c-myc gene is a proto-oncogene which is required for cell proliferation, transformation and death . c-myc mRNA has an alternative method of translation via internal ribosome entry where ribosomes are recruited to the IRES located in the 5'UTR thus bypassing the typical eukaryotic cap-dependent translation pathway.